Virginia Oliveira, Michele Munk Pereira
Núcleo de Pesquisa e Inovação em Ciências da Saúde (NUPICS), Faculdade de Farmácia, Universidade Federal de Juiz de Fora (UFJF), MG
Humberto de Mello Brandão
Embrapa Gado de Leite, Juiz de Fora, MG.
Marcos Antônio Fernandes Brandão
Núcleo de Pesquisa e Inovação em Ciências da Saúde (NUPICS), Faculdade de Farmácia, Universidade Federal de Juiz de Fora (UFJF), MG
Wagner Farid Gattaz, Nádia Rezende Barbosa Raposo
Laboratório de Neurociências (LIM-27), Departamento e Instituto de Psiquiatria da Faculdade de Medicina da Universidade de São Paulo (FMUSP).
Abstract:
Background: Carbon nanotubes (CNTs) are the most promising nanomaterials for therapeutic application in neurodegenerative diseases. Potential applications include systems for controlled drug delivery, electrical interfaces and substrates for cell growth. Objective: To describe the state of art, prospects and challenges of applying CNTs in neuroscience. Methods: There has been systematic search in Medline, Lilacs and SciELO, using the keywords “carbon nanotubes”, “drug delivery”, “electrical interface”, “tissue regeneration”, “neuroscience”, “nanotechnology” and “biocompatibility”, properly grouped. Results: The literature review showed controversies in studies on the biocompatibility of CNTs, although it has ratified its potential for neuromedicine and neuroscience. Discussion: These results highlight the need for modeling studies on the applications and interactions of nanostructures with biological systems.
Keywords:Carbon nanotubes, drug delivery, electrical interface, tissue regeneration, neurobiology