Liying Liu, Ce Chen
Wenzhou Seventh People’s Hospital, Wenzhou, China
Gongying Li
Department of Psychiatry, Institute of Mental Health, Psychiatric Genetics Laboratory (PSYG-Lab), Jining Medical University, Jining, China.
Xiaodong Lin, Deguo Jiang
Wenzhou Seventh People’s Hospital, Wenzhou, China
Hongjun Tian
Psychiatric-Neuroimaging-Genetics and Comorbidity Laboratory (PNGC-Lab), Tianjin Anding Hospital, Mental Healthy Teaching Hospital of Tianjin Medical University, Tianjin, China.
Xu Lang
Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China.
Chuanjun Zhuo, Lixue Qiu
Wenzhou Seventh People’s Hospital, Wenzhou, China.
Abstract:
Reciprocity of depressive and psychotic symptoms in patients with schizophrenia and major depression disorder (MDD), respectively, complicates differential psychiatric diagnosis. Notably, 60%-70% of schizophrenia patients experience moderate to severe depressive symptoms. Indeed, schizophrenia and MDD have been proposed to be variants of the same disorder, namely major psychiatric disorder. Notwithstanding, distinct functional brain characteristics of these two patient groups have been demonstrated. Additionally, patients with schizophrenia and MDD have been reported to have reduced and increased corpus callosum (CC) sizes, respectively. Thus, we have hypothesized that there may be a depressive-type schizophrenia.
Keywords:depressive and psychotic symptoms ,schizophrenia ,major depression disorder (MDD)