Objective: Current diagnostics for Sepsis 3.0 suffer from the lack of specific coagulative indicators for the risk and prognosis of both sepsis and septic shock. Our study seeks to augment the precision of risk assessment and prognosis for these conditions via integrating APACHE II, SOFA, and CDSS scores. Incorporating coagulation factors, we aim to refine the evaluation to further assist in clinical practice. Method: We selected 200 sepsis patients admitted to our department from 2019-2020, subjecting them to APACHE II, SOFA, and CDSS scoring. We then evaluated their 28-day prognosis using these independent and comprehensive scores, aiming to elucidate their interrelation and offer early indicators for sepsis prognosis. Results: In the sepsis cohort complicated with Disseminated Intravascular Coagulation (DIC), the 28-day mortality rate was significantly elevated (75.00%) in comparison to sepsis patients without DIC (34.56%). Additionally, APACHE II and SOFA scores in the sepsis-DIC subgroup were markedly higher than those in the non-DIC sepsis subgroup (both P<0.01). The septic shock cohort complicated with DIC similarly showed a higher 28-day mortality rate (77.77%) than the septic shock patients without DIC (53.96%). Moreover, the APACHE II and SOFA scores for the septic shock-DIC subgroup exceeded those in the non-DIC septic shock subgroup (all P<0.01). Overall, the group with DIC demonstrated a higher mortality rate (76.78%) than the group without DIC (43.05%), and their APACHE II and SOFA scores were significantly elevated (all P<0.01). The APACHE II, SOFA, and CDSS scores of patients who did not survive were significantly higher than those of the recovered patient group (all P<0.01). Conclusion: Incorporating APACHE II, SOFA, and CDSS scores can enhance the prognosis prediction capabilities for sepsis patients.