Abstract: Purpose:The application effect of a new nasal and facial pressure sore prevention component in preventing pressure injury caused by non-invasive breathing masks in elderly patients was investigated. Methods: From January 2020 to January 2022, 117 elderly patients who received noninvasive positive pressure ventilation treatment in a Grade-A tertiary hospital in Shanghai were selected as research subjects and randomly divided into a control group (59 cases) and a experiment group (58 cases). The control group used conventional skin care and gauze protection, while the experimental group used a new nasal and facial pressure sore prevention component to protect facial skin on the basis of conventional skin care. The intervention effects of the two groups were compared. Results: After treatment with non-invasive positive pressure ventilation and nasal mask for 3 and 7 days, the incidence of pressure injury in the experimental group was 0 and 1.7%, the subjective comfort score was 5.74 ± 1.753 and 5.62 ± 1.927, respectively, and the rate of dressing detachment was 6.9%, which were significantly better than those in the control group (P<0.05). The satisfaction scores of nursing staff in the four aspects of ease of operation, application replacement frequency, application replacement operation duration, and overall feeling were higher than those of the control group (P<0.05). Conclusion: The use of a new nasal and facial pressure sore prevention component can effectively prevent the occurrence of facial pressure injury in elderly patients with non-invasive ventilation, improve their subjective comfort, reduce the occurrence of dressing shedding, facilitate clinical operation by nurses, and save labor costs.